使用生育治疗怀孕的孩子可能患哮喘和湿疹的风险更高

使用生育治疗怀孕的孩子可能患哮喘和湿疹的风险更高：Children conceived using fertility treatment may be at higher risk of asthma and e

接受生育治疗的妇女所生的孩子与患哮喘、湿疹和其他相关过敏症的风险增加有关，尽管他们有父母的倾向。

发表在《人类生殖》杂志上的一项研究确定，母亲接受生育治疗的孩子在3岁时出现持续喘息的可能性比自然受孕的同龄人高55%。到7到9岁时，经医生证实，儿童患哮喘的可能性要高出56%。此外与未接受生育治疗的儿童相比，他们患湿疹的可能性高出69%，服用过敏相关药物的可能性高出46%。发现这些差异具有统计学意义，并调整了父母哮喘和其他危险因素。

“哮喘和过敏性疾病是影响儿童的一些最常见的慢性疾病，”马里兰州贝塞斯达国家儿童健康与人类发展研究所的Edwina Yeung博士和该研究的资深作者告诉《每日邮报》。“确定机制的一个重要研究方向将是澄清和揭示生育药物或程序本身对潜在生育力低下的影响。”

杨博士和她的研究人员研究了纽约57个县的5034名母亲以及她们在2008年至2010年间出生的6171名孩子。在他们的童年中期，有2056名儿童参加了后续问卷调查，以了解是否有哮喘或任何过敏症坚持。任何母亲都接受过的生育治疗，包括体外受精和排诱导（通过口服或注射）。

这项研究表明，生育治疗之间的共同生物学结果与使用这些治疗所孕育的儿童发展为哮喘之间存在潜在联系。尽管机制尚不清楚，但研究人员推测这可能导致受孕胎儿的激素水平超出正常生理范围。然而研究人员还推测，那些接受生育治疗的母亲可能更有可能表孩子接受医生的诊断。这可能是由于他们较高的社会经济背景，或者因为他们以前接受过生育治疗而更有可能寻求医疗护理。

“在我们更好地了解潜在机制之前，对临床实践的影响是有限的，”该研究的第一作者Kristen Polinski博士告诉Healio。

作者建议需要进行额外的研究，这些研究对于得出生育治疗或父母不孕症如何可能导致他们的孩子患哮喘和过敏症的风险更高的结论是必要的。

原文：

Children born to women who underwent fertility treatment are associated with an increased risk of developing asthma，eczema，and other related allergies，despite their parental predisposition.

A study published in Human Reproduction has determined that children whose mothers'received fertility treatment，were 55 percent more likely to have a persistent wheeze at age three than their naturally-conceived peers.By seven to nine years of age，children were 56 percent more likely to develop asthma verified by a physician.Moreover，they were 69 percent more likely to develop eczema and 46 percent more likely to be prescribed allergy-related medicines compared to children conceived without fertility treatment.These differences were found to be statistically significant，with adjustment for parental asthma and other risk factors.

'Asthma and allergic conditions are some of the most common chronic diseases affecting children，'Dr Edwina Yeung，of the National Institute of Child Health and Human Development in Bethesda，Maryland and senior author of the study told the Daily Mail.'An important research direction to pinpoint a mechanism will be to clarify and unravel the impacts of fertility medications or procedures themselves from underlying subfertility.'

Dr Yeung and her fellow researchers studied 5034 mothers，across 57 New York counties，and their 6171 children born between 2008 and 2010.Within the middle of their childhood 2056 children had taken part in a follow-up questionnaire to see if asthma or any allergies persisted.Fertility treatments that any mothers underwent，including IVF，and ovulation induction(via oral or injectables).

This study has indicated a potential link of a shared biological outcome between the fertility treatments，and the children conceived from using them，developing asthma.Although the mechanism is unknown，researchers theorised that this may have caused the conceived fetus to experience hormone levels outside the normal physiological range.However，researchers also speculate that those mothers who underwent fertility treatment may be more likely to receive diagnoses from physicians on behalf of their children.This could be due to their higher socioeconomic background or because they are more likely to seek medical care due to undergoing previous fertility treatments.

'Until we have a better understanding of an underlying mechanism，the implications for clinical practice are limited，'Dr Kristen Polinski first author of the study told Healio.

The authors have suggested that additional studies are needed，which are necessary to conclude how fertility treatment，or parental infertility，may result in their children presenting a higher risk for asthma and allergies.